Modeling and Stability Observation of Animal Models of Diabetic Hypertensive Rats

Objective: To investigate the method of establishment the rat model of hypertension and diabetes,and to observe the stability of the model.Methods: Diabetic hypertensive rat model was established by intraperitoneal injection of streptozotocin(STZ).16 spontaneously hypertensive rats(SHR) of 8-week-old were randomly divided into the control group and the model group.Replacement of 8 WKY rats of 8-week-old was chosen as normotensive control group.SHR intraperitoneal injection of STZ dose 55mg/kg body weight was given to establish the animal model of diabetic hypertensive rats.Results: Given the SHR by intraperitoneal injection of a small dose of STZ(55mg/kg) can successfully established diabetic hypertensive rat model.This method has the advantages of modeling a high success rate,low cost,built the stable model modeling.Conclusions: The stable and reliable diabetic hypertensive rat model was establish.