OBJECTIVE: To introduce the study progress and clinical application on antifungal drugs. METHODS: By analyzing the literature about the antifungal drugs at home and abroad, study progress and clinical application on antifungal drugs were reviewed by classification. RESULTS CONCLUTION: The study on the antifungal drugs is mainly concentrated on the structure reform and the discoveries of new antifungal drugs. In clinical, the antifungal drugs are being used according to its different characteristic.