Antibacterial properties and drug release study of cellulose acetate nanofibers containing ear-like Ag-NPs and Dimethyloxallyl Glycine/beta-cyclodextrin

Schematic diagram of CA/β-CD/DMOG nanofiber preparation process and Antibacterial activity. • Multifunctional drug-delivery nanofibers for sustained drug release and broad-spectrum antibacterial. • In-situ synthesis of silver nanoparticles on the surface of drug-loaded nanofibers. • A good balance of cytocompatibility, antimicrobial properties, mechanical properties and wettability. In this paper, a multifunctional wound dressing with sustained-release and antibacterial properties was prepared using cellulose acetate (CA) as the matrix and Dimethyloxallyl Glycine (DMOG) and silver nanoparticles (Ag-NPs) as the drug loading component. The scanning electron microscopy shows that the microstructure of the nanofibers is uniform and droplet free, and the diameters of CA and CA/β-CD/DMOG nanofibers are mainly concentrated in the range of 40–120 nm, and the diameters of CA/DMOG/Ag-NPs nanofibers are mainly concentrated in the range of 120–200 nm. In vitro release test confirms that the CA/DMOG/Ag-NPs nanofiber can slowly release DMOG within about 84 h, which abides by a typical diffusion, and the main driving force is the concentration gradient between the drug-carrying nanofibers and the releasing medium. The antibacterial performance test demonstrates that the material exhibits obvious antibacterial performance against both E. coli and B.subtilis bacteria with little adverse effects on cell viability proved by cell compatibility test. Taken together, CA/DMOG/Ag-NPs can be a wound dressing material with good application prospects to promote the healing of diabetic wounds.