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Developing a Diagnostic Multivariable Prediction Model for Urinary Tract Cancer in Patients Referred with Haematuria: Results from the IDENTIFY Collaborative Study

医学 癌症 排尿困难 膀胱癌 泌尿系统 恶性肿瘤 逻辑回归 置信区间 内科学 膀胱镜检查 泌尿科 肿瘤科
作者
Sinan Khadhouri,Kevin Gallagher,Kenneth MacKenzie,Taimur T. Shah,Chuanyu Gao,Sacha Moore,Eleanor Zimmermann,Eric Edison,Matthew Jefferies,Arjun Nambiar,Thineskrishna Anbarasan,Miles Mannas,Taeweon Lee,Giancarlo Marra,Juan Gómez Rivas,Gautier Marcq,Mark A. Assmus,Taha Uçar,Francesco Claps,M. Boltri,Giuseppe La Montagna,Tara Burnhope,Nkwam Nkwam,Tomas Austin,Nicholas E. Boxall,Alison Downey,Troy A. Sukhu,M. Antón-Juanilla,Sonpreet Rai,Yew-Fung Chin,Madeline Moore,Tamsin Drake,James S.A. Green,Beatriz Goulão,Graeme MacLennan,Matthew E. Nielsen,John McGrath,Veeru Kasivisvanathan,Aasem Chaudry,Abhishek Sharma,Adam Bennett,Adnan Ahmad,Ahmed Abroaf,Ahmed Musa Suliman,Aimee Lloyd,Alastair McKay,Albert J. Wong,Alberto Silva,Alexandre Schneider,Alison MacKay,Allen Knight,Alkiviadis Grigorakis,Amar Bdesha,Amy Nagle,Ana Cebola,Ananda Kumar Dhanasekaran,Andraž Kondža,André da Silva Barcelos,Andrea Benedetto Galosi,Andrea Ebur,Andrea Minervini,Andrew Russell,Andrew Webb,Ángel García de Jalón,Ankit A. Desai,Anna Czech,Anna Mainwaring,Anthony Adimonye,Arighno Das,Arnaldo Figueiredo,Arnauld Villers,Artur Lemiński,Arvinda Chippagiri,Asim Ahmed Lal,Asıf Yıldırım,Athanasios Marios Voulgaris,A. Uzan,Aye Moh Moh Oo,Ayman Younis,Bachar Zelhof,Bashir Mukhtar,Ben Ayres,Ben Challacombe,Benedict T. Sherwood,Benjamin T. Ristau,Billy Lai,Brechtje Nellensteijn,Brielle Schreiter,Carlo Trombetta,Catherine Dowling,Catherine Hobbs,Cayo Augusto Estigarribia Benitez,C. Lebâcle,Cherrie Wing Yin Ho,Chi‐Fai Ng,Chloe Mount,Chon Meng Lam,Chris Blick,C. T. A. Brown,Christopher Gallegos,Claire Higgs,Clíodhna Browne,Conor McCann,Cristina Plaza Alonso,Daniel Beder,Daniel L. Cohen,Daniel Gordon,Daniel Wilby,Danny Gordon,David Hrouda,David Hua Wu Lau,Dávid Karsza,David Mak,David Martin-Way,Denula Suthaharan,Dhruv Patel,Diego M. Carrión,Donald Nyanhongo,Edward Bass,Edward Mains,Edwin Chau,Elba Canelon Castillo,Elizabeth Day,Elsayed Desouky,Emily Gaines,Emma Papworth,Emrah Yürük,Enes Kılıç,Eoin Dinneen,Erika Palagonia,Évanguelos Xylinas,Faizan Khawaja,Fernando Cimarra,F. Bardet,Francesca Kum,Francesca Peters,Gábor Kovács,Geroge Tanasescu,Giles Hellawell,G. Tasso,Gitte Wrist Lam,Giuseppe La Montagna,G. Pizzuto,Gordan Lenart,Graeme MacLennan,Günal Özgür,Hai Bi,Hannah Lyons,Hannah Warren,Hashim U. Ahmed,Helen Simpson,Helena Burden,Heléna Gresty,Hernado Rios Pita,Holly Clarke,Hosam Serag,Howard Kynaston,Hugh Crawford-Smith,Hugh Mostafid,Hugo Otaola-Arca,Hui Fen Koo,Ibrahim Ibrahim,I. Ouzaïd,Ignacio Puche‐Sanz,Igor Tomašković,İlker Tınay,Iqbal Sahibzada,Isaac Thangasamy,Iván Revelo Cadena,Jacques Irani,Jakub Udzik,James E. Brittain,James W.F. Catto,James Green,James Tweedle,Jamie Borrego Hernando,Jamie Leask,Jas Kalsi,Jason Frankel,Jason Toniolo,Jay D. Raman,Jean Courcier,Jeevan Kumaradeevan,Jennifer L. Clark,Jennifer M. Jones,Jeremy Yuen‐Chun Teoh,John Iacovou,John D. Kelly,J. Patrick Selph,Jonathan Aning,Jon Deeks,Jonathan Cobley,Jonathan Olivier,Jonny Maw,J.A. Herranz-Yague,Jose Ignacio Nolazco,J.M. Cózar-Olmo,Joseph Bagley,Joseph Jelski,Joseph M. Norris,Joseph R. Testa,Joshua J. Meeks,Juan C. Hernández,Juan Luis Vásquez,Karen Randhawa,Karishma Dhera,Katarzyna Gronostaj,Kathleen Al Houlton,Kathleen J. Lehman,Kathryn Gillams,Kelvin Adasonla,Kevin M. Brown,Kevin Murtagh,Kiki Mistry,Kim Davenport,Kosuke Kitamura,Laura Derbyshire,Laurence P. Clarke,Lawrie Morton,Levin Martínez,Louise Goldsmith,Louise Paramore,Laurent Cormier,Lucio Dell’Atti,Lucy A. M. Simmons,Luis Martínez‐Piñeiro,Luis Rico Romero,Luke Chan,Luke Forster,Lei Ma,Madeline Moore,María Camacho Gallego,María José Freire Silva,Mark Emberton,Mark Feneley,M. Antón-Juanilla,Marta Viridiana Muñoz Rivero,Matea Pirša,Matteo Tallè,Matthew Crockett,Matthew Liew,Matthew Trail,Max Peters,Meghan Cooper,Meghana Kulkarni,Michael Ager,Min He,Mo Li,Mohamed Omran Breish,Mohamed Tarin,Mohammed Aldiwani,Mudit Matanhelia,M. Asghar Pasha,Mustafa Kaan Akalın,Nasreen Abdullah,Nathan Hale,Neha Gadiyar,Neil J. Kocher,Nicholas Bullock,Nicholas Campain,Nicola Pavan,Nihad Al-Ibraheem,Nikita Bhatt,Nishant Bedi,Nitin Shrotri,Niyati Lobo,Olga Balderas,Omar Kouli,Otakar Čapoun,Pablo Oteo Manjavacas,Paolo Gontero,Paramananthan Mariappan,Patricio García Marchiñena,Paul Erotocritou,Paul Sweeney,P. Planelles,Peter Acher,Peter C. Black,Peter K Osei-Bonsu,Peter Busch Østergren,Peter Smith,Peter‐Paul M. Willemse,Piotr Chłosta,Qurrat Ul Ain,Rachel Barratt,Rachel Esler,Raihan Khalid,Ray T. Hsu,Remigiusz Stamirowski,Reshma Mangat,Ricardo Alcántara‐de la Cruz,Ricky Ellis,Robert Adams,Robert Hessell,Robert J.A. Oomen,Robert McConkey,Robert O. Ritchie,Roberto Jarimba,R. Chahal,Rosado Mario Andres,Rosalyn Hawkins,Rotimi A. David,R.P. Manecksha,Shruti Agrawal,Syed Sami Hamid,Samuel Deem,Sanchia S. Goonewardene,Satchi Swami,Shingo Hori,Shahid A. Khan,Shakeel Mohammud Inder,Shanthi Sangaralingam,Shekhar Marathe,Sheliyan Raveenthiran,Shigeo Horie,Shamik Sengupta,Sian Parson,Sidney Parker,Simon Hawlina,Simon Williams,Sandra Mazzoli,S.G. Kata,Sofia Pinheiro Lopes,Sônia R. T. S. Ramos,Sonpreet Rai,Sophie Rintoul‐Hoad,S. O’Meara,Steve Morris,Stacey Turner,Stefano Venturini,Stephanos Almpanis,Steven Joniau,Sunjay Jain,Susan Mallett,Sven Nikles, Shahzad,Sylvia Yan,Taeweon Lee,Taha Uçar,Tamsin Drake,Tarq Aziz Toma,Teresa Cabañuz Plo,Thierry Bonnin,Tim Muilwijk,Tim Wollin,Timothy Shun Man Chu,T. Appanna,Tom Brophy,Tom Ellul,Tomas Austin,Tomaž Smrkolj,Tracey Rowe,Troy A. Sukhu,Trushar R. Patel,Tullika Garg,Turhan Çaşkurlu,Uroš Bele,Usman M. Haroon,V. Crespo-Atìn,Victor Parejo Cortes,Victoria Capapé Poves,Vincent J. Gnanapragasam,Vineet Gauhar,Vinnie During,V. Bharath Kumar,Vojtěch Fiala,Wasim Mahmalji,Wayne Lam,Yew Fung Chin,Yigit Filtekin,Yih Chyn Phan,Youssed Ibrahim,Zachary A. Glaser,Zainal Adwin Abiddin,Zijian Qin,Zsuzsanna Zotter,Zulkifli Md Zainuddin
出处
期刊:European urology focus [Elsevier BV]
卷期号:8 (6): 1673-1682 被引量:13
标识
DOI:10.1016/j.euf.2022.06.001
摘要

Patient factors associated with urinary tract cancer can be used to risk stratify patients referred with haematuria, prioritising those with a higher risk of cancer for prompt investigation.To develop a prediction model for urinary tract cancer in patients referred with haematuria.A prospective observational study was conducted in 10 282 patients from 110 hospitals across 26 countries, aged ≥16 yr and referred to secondary care with haematuria. Patients with a known or previous urological malignancy were excluded.The primary outcomes were the presence or absence of urinary tract cancer (bladder cancer, upper tract urothelial cancer [UTUC], and renal cancer). Mixed-effect multivariable logistic regression was performed with site and country as random effects and clinically important patient-level candidate predictors, chosen a priori, as fixed effects. Predictors were selected primarily using clinical reasoning, in addition to backward stepwise selection. Calibration and discrimination were calculated, and bootstrap validation was performed to calculate optimism.The unadjusted prevalence was 17.2% (n = 1763) for bladder cancer, 1.20% (n = 123) for UTUC, and 1.00% (n = 103) for renal cancer. The final model included predictors of increased risk (visible haematuria, age, smoking history, male sex, and family history) and reduced risk (previous haematuria investigations, urinary tract infection, dysuria/suprapubic pain, anticoagulation, catheter use, and previous pelvic radiotherapy). The area under the receiver operating characteristic curve of the final model was 0.86 (95% confidence interval 0.85-0.87). The model is limited to patients without previous urological malignancy.This cancer prediction model is the first to consider established and novel urinary tract cancer diagnostic markers. It can be used in secondary care for risk stratifying patients and aid the clinician's decision-making process in prioritising patients for investigation.We have developed a tool that uses a person's characteristics to determine the risk of cancer if that person develops blood in the urine (haematuria). This can be used to help prioritise patients for further investigation.
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