ISP-Net: Fusing features to predict ischemic stroke infarct core on CT perfusion maps

Acute ischemic stroke is one of the leading death causes. Delineating stoke infarct core in medical images plays a critical role in optimal stroke treatment selection. However, accurate estimation of infarct core still remains challenging because of 1) the large shape and location variation of infarct cores; 2) the complex relationships between perfusion parameters and final tissue outcome.We develop an encoder-decoder based semantic model, i.e., Ischemic Stroke Prediction Network (ISP-Net), to predict infarct core after thrombolysis treatment on CT perfusion (CTP) maps. Features of native CTP, CBF (Cerebral Blood Flow), CBV (Cerebral Blood Volume), MTT (Mean Transit Time), Tmax are generated and fused with five-path convolutions for comprehensive analysis. A multi-scale atrous convolution (MSAC) block is firstly put forward as the enriched high-level feature extractor in ISP-Net to improve prediction accuracy. A retrospective dataset which is collected from multiple stroke centers is used to evaluate the performance of ISP-Net. The gold standard infarct cores are delineated on the follow-up scans, i.e., non-contrast CT (NCCT) or MRI diffusion-weighted image (DWI).In clinical dataset cross-validation, we achieve mean Dice Similarity Coefficient (DSC) of 0.801, precision of 81.3%, sensitivity of 79.5%, specificity of 99.5%, Area Under Curve (AUC) of 0.721. Our approach yields better outcomes than several advanced deep learning methods, i.e., Deeplab V3, U-Net++, CE-Net, X-Net and Non-local U-Net, demonstrating the promising performance in infarct core prediction. No significant difference of the prediction error is shown for the patients with follow-up NCCT and follow-up DWI (P >0.05).This study provides an approach for fast and accurate stroke infarct core estimation. We anticipate the prediction results of ISP-Net could offer assistance to the physicians in the thrombolysis or thrombectomy therapy selection.