医学
慢性阻塞性肺病
肺活量
肺功能测试
指南
肺活量测定
生活质量(医疗保健)
内科学
物理疗法
临床终点
痰
临床试验
哮喘
肺功能
肺
扩散能力
护理部
病理
肺结核
作者
Yasuhiro Setoguchi,Shinyu Izumi,Hidenori Nakamura,Shigeo Hanada,Kohei Marumo,Atsuko Kurosaki,Shouichi Akata
标识
DOI:10.1517/14656566.2015.1074678
摘要
To investigate the potential beneficial effects of guideline-based pharmacological therapy on pulmonary function and quality of life (QOL) in Japanese chronic obstructive pulmonary disease (COPD) patients without prior treatment.Multicenter survey, open-label study of 49 Japanese COPD patients aged ≥ 40 years; outpatients with >10 pack years of smoking history; ratio of forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) < 70%; predicted FEV1 < 80%; treated with bronchodilators and/or inhaled corticosteroids as maintenance therapy until week 48.The primary endpoint was change in pulmonary function (trough FEV1, trough FVC); secondary endpoints were QOL and physical activity at 48 weeks after initiation of therapy.Airway reversibility was confirmed in untreated patients. Significant changes over time were not observed for FEV1 and FVC, indicating lung function at initiation of treatment was maintained during the observation period. COPD assessment test scores showed statistical and clinical improvements. Cough, sputum, breathlessness, and shortness of breath were significantly improved.Lung function and QOL of untreated Japanese COPD patients improved and improvements were maintained by performing a therapeutic intervention that conformed to published guidelines.
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