BACKGROUND AND OBJECTIVE: To describe a new approach for in-office air-fluid exchange. PATIENTS AND METHODS: This manuscript describes a procedural technique. A retrospective chart review of three patients on whom the procedure was performed is presented. RESULTS: The authors have performed this novel procedure on three eyes of three patients. All patients were followed for at least 3 months after the procedure. No short-term complications occurred, and no secondary procedures were required to achieve a near-complete air-fluid exchange. CONCLUSION: This novel technique is a reliable and reproducible procedure that allows for in-office air-fluid exchange with good results in this small cohort of patients. [ Ophthalmic Surg Lasers Imaging Retina . 2018;49:799–801.]