Formation of Azomethines from 2-Aminothiazoles and (Heterocyclic) Aromatic Aldehydes

Reexamination of previous work and new studies show that the reactions of 2-aminothiazoles with (heterocyclic) aromatic aldehydes are not straightforward; there are wide divergencies in behaviour between the various amine-aldehyde pairs. Simple efficient procedures for preparing 2-(alkylideneamino)thiazole derivatives and [bis(thiazol-2-ylamino)methyl]arenes have been developed.