Photothermally triggered silk fibroin microneedles with coordinated gallic acid–iron networks for synergistic infected burn wound therapy

) during the early stage of wound healing, and then gradually degrades in the subsequent phase to release iron ions and gallic acid, conferring durable antioxidant, anti-inflammatory, and chemodynamic effects. Simultaneously, the progressive degradation of SFMSs can activate endogenous regenerative pathways, thereby promoting collagen synthesis and angiogenesis. In a murine infected burn model, the MN patch significantly accelerates wound closure, reduces pro-inflammatory cytokines (TNF-α, IL-6), and enhances tissue remodeling. This work presents a synergistic and spatiotemporally programmable strategy for infected burn healing through the combination of photothermal, chemodynamic, antioxidant, and regenerative functions.