Molecularly designed star-shaped PLA-based polymers with enhanced piezoelectricity for ultrasound-driven wound healing

wound healing assessments confirm that ultrasound (US)-activated sPEG-PLLA-25k membranes significantly promote cell proliferation and migration, and achieve a higher wound closure rate compared to the PLLA-US group. This work has made breakthroughs in the first attempt to enhance the piezoelectricity of PLA-based materials by a molecular design strategy and developed a dressing with excellent piezoelectric properties and biocompatibility, which provides new materials and strategies for a self-driven electrical stimulation wound healing system.