Development of dual-function optical microneedle lens array for skin cancer treatment by photodynamic therapy

human NativeSkin® model. Additionally, we coated two clinically relevant PSs, 5-aminolevulinic acid and rose bengal. Finally, we demonstrated that a PS-coated OMLA effectively delivered both light and the PS, resulting in effective PDT-induced cytotoxicity in 2D and 3D melanoma cell models.