The first report of Alzheimer's disease

Alois Alzheimer (1864-1915), a German psychiatrist and neuropathologist, was the first to describe the clinical and pathological features of a then unrecognised brain disease. In 1895, Alzheimer described “arteriosclerotic brain atrophy”. 1 Alzheimer A Die arteriosklertische atrophie des gehirns. Allg Z Psychiat. 1895; 51: 809-811 Google Scholar This notion was important for differentiating arterosclerotic dementia from general paralysis since, in those days, syphilis was considered to be the most common form of presenile dementia. Safety and efficacy of dual-lead thalamic deep brain stimulation for patients with treatment-refractory multiple sclerosis tremor: a single-centre, randomised, single-blind, pilot trialDual lead thalamic DBS might be a safe and effective option for improving severe, refractory multiple sclerosis tremor. Larger studies are necessary to show whether this technique is widely applicable, safe in the long-term, and effective in treating multiple sclerosis tremor or other severe tremor disorders. Full-Text PDF