硅氢加成
化学
硅烷
马尔科夫尼科夫法则
芳基
催化作用
选择性
钴
区域选择性
炔烃
有机化学
硅烷化
亚胺
配体(生物化学)
药物化学
组合化学
烷基
受体
生物化学
硅烷
作者
Maciej Skrodzki,Victor Ortega Garrido,Aurelio G. Csákÿ,Piotr Pawluć
标识
DOI:10.1016/j.jcat.2022.05.002
摘要
The search for simple and easy-to-synthesize ligands for bench stable cobalt (pre)catalysts that would ensure high activity and selectivity in alkyne hydrosilylation reactions is an interesting current challenge. Herein, we report that a cobalt(II) complex bearing pyrimidine-imine-2H-imidazole ligand activated by LiHBEt3 exhibits not only high catalytic activity, but also unprecedented tolerance towards tertiary silanes in highly regioselective Markovnikov hydrosilylation of aliphatic and aromatic terminal alkynes to give α-vinylsilanes. In addition, a variety of 1-aryl-2-(trimethylsilyl)acetylenes have been hydrosilylated efficiently by diphenylsilane in the presence of [Co(L)Cl2]/LiHBEt3 catalytic system to yield (E)-1-aryl-1,2-bis(silyl)ethenes with high selectivity. Such selectivity is very rarely observed for cobalt-catalyzed hydrosilylation of silylacetylenes.
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