恶病质
背景(考古学)
癌症
病态的
祖细胞
癌变
干细胞
医学
人口
生物
生物信息学
癌症研究
免疫学
病理
内科学
环境卫生
遗传学
古生物学
作者
Daniela Di Girolamo,Shahragim Tajbakhsh
标识
DOI:10.1186/s13619-022-00108-9
摘要
Cancers remain among the most devastating diseases in the human population in spite of considerable advances in limiting their impact on lifespan and healthspan. The multifactorial nature of cancers, as well as the number of tissues and organs that are affected, have exposed a considerable diversity in mechanistic features that are reflected in the wide array of therapeutic strategies that have been adopted. Cachexia is manifested in a number of diseases ranging from cancers to diabetes and ageing. In the context of cancers, a majority of patients experience cachexia and succumb to death due to the indirect effects of tumorigenesis that drain the energy reserves of different organs. Considerable information is available on the pathophysiological features of cancer cachexia, however limited knowledge has been acquired on the resident stem cell populations, and their function in the context of these diseases. Here we review current knowledge on cancer cachexia and focus on how tissues and their resident stem and progenitor cell populations are individually affected.
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