化学
对映选择合成
催化作用
轴手性
组合化学
密度泛函理论
喹啉酮
计算化学
轴对称性
相(物质)
立体化学
有机化学
结构工程
工程类
作者
Ming Pan,Yuanhu Shao,Qun Zhao,Xin Li
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-12-20
卷期号:24 (1): 374-378
被引量:33
标识
DOI:10.1021/acs.orglett.1c04028
摘要
N-N axially chiral skeletons are significant structural motifs in natural products, pharmaceuticals, and functional materials. Herein we disclose a method for the asymmetric synthesis of N-N axially chiral compounds by phase-transfer catalysis. A wide range of N-N axially chiral quinazolinone derivatives were prepared in high yields with excellent stereoselectivities. Furthermore, the synthetic utility of the protocol was proved by large-scale reaction and transformation of the product. Density functional theory calculations provide insight into the mechanism.
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