医学
慢性阻塞性肺病
内科学
免疫学
杜皮鲁玛
炎症
嗜酸性粒细胞
哮喘
作者
Surya P. Bhatt,Klaus F. Rabe,Nicola A. Hanania,Claus Vogelmeier,Jeremy Cole,Mona Bafadhel,Stephanie A. Christenson,Alberto Papi,Dave Singh,Elizabeth Laws,Leda Mannent,Naimish Patel,Heribert Staudinger,George D. Yancopoulos,Eric Mortensen,Bolanle Akinlade,Jennifer Maloney,Xin Lu,Déborah Bauer,Ashish Bansal
标识
DOI:10.1056/nejmoa2303951
摘要
Among patients with COPD who had type 2 inflammation as indicated by elevated blood eosinophil counts, those who received dupilumab had fewer exacerbations, better lung function and quality of life, and less severe respiratory symptoms than those who received placebo. (Funded by Sanofi and Regeneron Pharmaceuticals; BOREAS ClinicalTrials.gov number, NCT03930732.).
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