Discovery of a photoactivatable dimerized STING agonist based on the benzo[b]selenophene scaffold

The first photoactivatable STING agonist, caged-diBSP01, is presented based on a novel and potent dimerized STING agonist diBSP01. Caged-diBSP01 allowed spatiotemporal control of STING activation by light, which was well characterized both in vitro and in vivo .