磁刺激
自闭症
自闭症谱系障碍
心理学
固定(群体遗传学)
凝视
人口
听力学
眼动
物理医学与康复
神经科学
医学
发展心理学
刺激
环境卫生
精神分析
物理
光学
作者
Li Tian,Shuai Ma,Yin Li,M M Huanjun Zhao,Chang Xu,Chen Wang,Xin Zhang,Lei Gao
标识
DOI:10.3389/fnins.2023.1188648
摘要
Background Transcranial magnetic stimulation (TMS) has been introduced into the intervention of autism spectrum disorders (ASD) as a possible new therapeutic option for modifying pathological neuroplasticity. However, the stimulating protocols of rTMS for ASD have not been approved unanimously, which affects the clinical popularization and application of rTMS. In addition, there is little research on the improvement of social processing of autistic children by rTMS. Methods We explored the clinical efficacy of rTMS and improvement of face processing with the protocol of left high-frequency and right low-frequency on bilateral dorsolateral prefrontal cortex (DLPFC), with a sample of 45 ASD participants aged 2–18. Results Our results showed that both the score on the Childhood Autism Rating Scale (CARS) and the fixations on the eyes of the human faces improved by two-session rTMS intervention, except for the percentage of eyes fixation. The mediation analysis indicated the item of “Adaptation to Change” of CARS mediated dominantly the improvement of eye-gaze behavior of ASD participants by rTMS. Conclusion Our study revealed the mechanism of rTMS in improving the eye-gaze behavior of the autism population, deepened the understanding of the function of rTMS in treating autistic social disorders, and provided a reference for combined treatment for ASD.
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