Phentolamine: more than just an adrenergic blocker – a pathway to a potential analgesic?

Phentolamine, a non-selective α-adrenergic antagonist traditionally used for vascular conditions and local anesthetic reversal, may have properties as a modulator of pain pathways. In this study[1][1] using ex vivo preparations from mice, pigs, and humans, phentolamine decreased compound action