Diffusion Tensor Imaging along the Perivascular Space for Characterizing Cerebral Interstitial Fluid Dynamics in Alzheimer Disease: A Systematic Review and Meta-Analysis

The DTI-ALPS technique showed significant differences among cognitive groups across the AD continuum and was associated with cognitive scores and brain amyloidosis. This provides further evidence that DTI-ALPS could be useful in detecting altered cerebral interstitial fluid dynamics in MCI and AD.