Identification of Bruceine A as a novel HSP90AB1 inhibitor for suppressing hepatocellular carcinoma growth

This study establishes HSP90AB1 as the primary target of BRA, which exerts its anti-HCC effects through modulation of downstream chaperones PIK3CG, EGFR, and KDM5C. These findings highlight the therapeutic potential of BRA in HCC and suggest that HSP90AB1 represents a promising target for future drug development.