芳香烃受体
环境化学
生物测定
邻苯二甲酸二丁酯
化学
气相色谱-质谱法
质谱法
色谱法
生物
生物化学
有机化学
遗传学
转录因子
基因
作者
Chun‐Mao Yuan,Yuqi Zeng,Xiaohong Yan,Jiwen Luo,Lixuan Zeng,Yu Bon Man,Bingyan Lan,Yuan Kang
出处
期刊:Chemosphere
[Elsevier]
日期:2024-04-01
卷期号:: 142108-142108
标识
DOI:10.1016/j.chemosphere.2024.142108
摘要
Numerous studies reported the concentration of agonists of aryl hydrocarbon receptor (AhR) in indoor dust by target chemical analysis or the biological effects of activating the AhR by indoor extracts, but the major AhR agonists identification in indoor dust were rarely researched. In the present study, the indoor dust samples were collected for 7-ethoxyresorufin O-deethylase (EROD) assay and both non-targeted and targeted chemical analysis for AhR agonists by gas chromatography quadrupole time-of-flight mass spectrometry and gas chromatography–mass spectrometry analysis. Coupled with non-targeted analysis and toxicity Forecaster (ToxCast)/Tox21 database, 104 ToxCast chemicals were screened to be able to induce EROD response. The combination of targeted chemical analyses and biological effects evaluation indicated that PAHs, dibutyl phthalate (DBP) and Cypermethrin might be the important AhR-agonists in different indoor dust and mainly contributed in 1.84% to 97.56 % (median: 26.62%) of total observed biological effects through comparing toxic equivalency quotient derived from chemical analysis with biological equivalences derived from bioassay. DBP and cypermethrin seldom reported in the analysis of AhR agonists should raise great concern. In addition, the present results in experiment of synthetic solution of 4 selected AhR-agonists pointed out that some unidentified AhR agonists existed in indoor dust.
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