磁共振成像
放射治疗
分子成像
核磁共振
磁共振光谱成像
化学
材料科学
核医学
医学
放射科
体内
物理
生物技术
生物
作者
Ao Rong,Haoyu Wang,Chaoqun Nie,Zhaoguo Han,Miao Zhou,Olagbaju Oluwatosin Atinuke,Kaiqi Wang,Xiance Wang,Shuang Liu,Jun Zhao,Wenju Qiao,Xiang Sun,Linzhi Wu,Xilin Sun
标识
DOI:10.1038/s41467-023-42286-3
摘要
Recently, radiotherapy (RT) has entered a new realm of precision cancer therapy with the introduction of magnetic resonance (MR) imaging guided radiotherapy systems into the clinic. Nonetheless, identifying an optimized radiotherapy time window (ORTW) is still critical for the best therapeutic efficacy of RT. Here we describe pH and O2 dual-sensitive, perfluorooctylbromide (PFOB)-based and glycerol-weighted chemical exchange saturation transfer (CEST) nano-molecular imaging probes (Gly-PFOBs) with dual fluorine and hydrogen proton based CEST MR imaging properties (19F/1H-CEST). Oxygenated Gly-PFOBs ameliorate tumor hypoxia and improve O2-dependent radiotherapy. Moreover, the pH and O2 dual-sensitive properties of Gly-PFOBs could be quantitatively, spatially, and temporally monitored by 19F/1H-CEST imaging to optimize ORTW. In this study, we describe the CEST signal characteristics exhibited by the glycerol components of Gly-PFOBs. The pH and O2 dual-sensitive Gly-PFOBs with19F/1H-CEST MR dual-modality imaging properties, with superior therapeutic efficacy and biosafety, are employed for sensitive imaging-guided lung cancer RT, illustrating the potential of multi-functional imaging to noninvasively monitor and enhance RT-integrated effectiveness.
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