化学
废止
催化作用
组合化学
氧化还原
卡宾
功能群
基质(水族馆)
立体化学
有机化学
海洋学
地质学
聚合物
作者
Pothapragada S. K. Prabhakar Ganesh,P. Muthuraja,Purushothaman Gopinath
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-11-14
卷期号:25 (46): 8361-8366
被引量:1
标识
DOI:10.1021/acs.orglett.3c03495
摘要
We herein report the Rh(III) catalyzed redox-neutral C–H activation/[5 + 2] annulation of aroyl hydrazides with sulfoxonium ylides as safe carbene precursors. The reaction shows excellent functional group tolerance, broad substrate scope, and scalability. We demonstrated the synthetic utility of the protocol via the synthesis of various diazepam drug analogues, late-stage functionalization of probenecid drug, and large scale synthesis. Finally, kinetic studies revealed C–H activation as the rate-determining step.
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