代谢工程
合成生物学
系统生物学
基因组工程
生化工程
可持续生产
计算机科学
系统体系工程
生产(经济)
系统工程
计算生物学
工程类
生物
系统设计
基因组
基因组编辑
酶
生物化学
宏观经济学
基因
经济
作者
Tae-Hee Han,Alisher Nazarbekov,Xuan Zou,Sang Yup Lee
标识
DOI:10.1016/j.copbio.2023.103004
摘要
Systems metabolic engineering, which integrates metabolic engineering with systems biology, synthetic biology, and evolutionary engineering, has revolutionized the sustainable production of fuels and materials through the creation of efficient microbial cell factories. Recent advancements in systems metabolic engineering targeting different biological components of the host cell have enabled the creation of highly productive microbial cell factories. This article provides a review of the recent tools and strategies used for enzyme-, genetic module-, pathway-, flux-, genome-, and cell-level engineering, supported by illustrative examples. Furthermore, we highlight recent trends in systems metabolic engineering, which involve the application of multiple tools discussed in this review. Finally, the paper addresses the challenges and perspectives of transitioning academic-level metabolic engineering studies to commercial-scale production.
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