The application of the Fischer indole synthesis in medicinal chemistry

The indole ring system is an important scaffold in a great number of biologically significant molecules and hence there are numerous methods to access this heterocyclic ring system. The Fischer indole reaction is one of the oldest methods, and due to its versatility, it is a widely employed method of preparing substituted indoles. This review will cover the period from 2016 to June 2022 and will focus on the application of the method in the area of medicinal chemistry.