Dual-mode nanoprobes for reactive oxygen species scavenging and treatment of acute lung injury

• CeO 2 :Yb 7 Tm 0.5 with a butterfly-like structure of upconversion nanoparticles (UCNPs) with multiple enzyme-mimicking ability. • CeO 2 :Yb 7 Tm 0.5 UCNPs possess catalase and glutathione peroxidase-mimicking enzyme properties that can be exploited to treat acute lung injury (ALI). • The CeO 2 :Yb 7 Tm 0.5 UCNPs turn blue, green, white, and red under upconversion luminescence with increasing temperature from 298 to 358 K. Oxidative stress plays an important role in acute and chronic inflammatory diseases. However, the clinical treatment options for oxidative stress-related diseases are limited. Nanozyme with excellent reactive oxygen species (ROS) catalytic capacity are promising for preventing ROS-related inflammation. Herein, we designed CeO 2 :Yb 7 Tm 0.5 with a butterfly-like structure of upconversion nanoparticles (UCNPs) with enzyme-mimicking ability. The CeO 2 :Yb 7 Tm 0.5 UCNPs have catalase and glutathione peroxidase-mimicking enzyme properties, which can treat acute lung injury (ALI). The CeO 2 :Yb 7 Tm 0.5 UCNPs turn blue, green, white, and red under upconversion luminescence with increasing temperature from 298 K to 358 K. Here, the changing of color are examined over the temperature range of in 298K-373 K in 10 K increments. Maximum absolute and relative sensitivities ( S a and S r ) of 2.3% K -1 and 2.7% K −1 are obtained at 298 K and 373 K, respectively. The butterfly-like structure of CeO 2 :Yb/Tm is promising for biological application, such as accurate cell temperature detection, bio-catalysis diagnostics and ALI treatment.