秀丽隐杆线虫
生物
长寿
下调和上调
微量营养素
氧化应激
模式生物
细胞生物学
脂褐素
遗传学
谷胱甘肽
基因
酶
生物化学
有机化学
化学
作者
Chaweewan Sirakawin,Dongfa Lin,Zongqing Zhou,Xiaoxin Wang,Raymond J. Kelleher,Shihua Huang,Wei-Biao Long,André Pires-daSilva,Yu Liu,Jingjing Wang,Ilya A. Vinnikov
摘要
Abstract Vitamin A (VA) is a micronutrient essential for the physiology of many organisms, but its role in longevity and age‐related diseases remains unclear. In this work, we used Caenorhabditis elegans to study the impact of various bioactive compounds on lifespan. We demonstrate that VA extends lifespan and reduces lipofuscin and fat accumulation while increasing resistance to heat and oxidative stress. This resistance can be attributed to high levels of detoxifying enzymes called glutathione S‐transferases, induced by the transcription factor skinhead‐1 (SKN‐1). Notably, VA upregulated the transcript levels of skn‐1 or its mammalian ortholog NRF2 in both C. elegans , human cells, and liver tissues of mice. Moreover, the loss‐of‐function genetic models demonstrated a critical involvement of the SKN‐1 pathway in longevity extension by VA. Our study thus provides novel insights into the molecular mechanism of anti‐aging and anti‐oxidative effects of VA, suggesting that this micronutrient could be used for the prevention and/or treatment of age‐related disorders.
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