三七
医学
慢性阻塞性肺病
随机对照试验
科克伦图书馆
荟萃分析
血液粘度
部分凝血活酶时间
中医药
血瘀
内科学
药理学
病理
凝结
替代医学
作者
Ruguang Zhou,Jie Zhang,Wen Zhang,Xinyu Zhang,Haiyan Zhang,Xiaohu Shi,Qingqing Wang,Qiong Zhang,Zhiwei He
出处
期刊:Phytomedicine
[Elsevier]
日期:2024-03-01
卷期号:125: 155244-155244
标识
DOI:10.1016/j.phymed.2023.155244
摘要
Panax notoginseng saponins (PNS) are the primary active components of an ancient Chinese herb Panax notoginseng. Hypercoagulable state of blood (HCS) is an independent risk factor and a cause of death in chronic obstructive pulmonary disease (COPD). Several vivo studies have demonstrated the use of PNS preparations for treating COPD with HCS. This study aimed to systematically evaluate the clinical efficacy and safety of PNS preparations in treating COPD with HCS. Meta-analysis of the randomized controlled trials (RCTs) was conducted to review data. RCTs on the treatment of COPD with HCS and PNS preparations were searched from PubMed, Cochrane Library, Embase, Web of Science, Chinese National Knowledge Infrastructure, Vip Information Database, Wanfang data, and Chinese Biomedical Literature Database. Relevant data were extracted from the included studies and methodological quality evaluation was performed. R language (version 4.2.3) was applied for the meta-analysis. Twenty RCTs involving 1831 patients were analyzed. The results revealed that PNS preparations considerably increased the total clinical efficiency, improved forced expiratory volume in one second percent of predicted, and forced expiratory volume/forced vital capacity ratio. Further, PNS preparations improved fibrinogen, plasma d-dimer, whole blood viscosity at high cut, whole blood viscosity at low cut, and plasma viscosity levels. The results obtained for activated partial thromboplastin and prothrombin times were not statistically significant. Finally, PNS preparations increased partial pressure of oxygen and decreased carbon dioxide pressure. This is the first relatively comprehensive systematic review of the clinical efficacy and safety of PNS preparations for treating COPD with HCS. The study revealed that PNS preparations considerably improve lung function, hypoxia, and blood hypercoagulability in patients with COPD and HCS without increasing the risk of hemorrhage and has a good safety profile; therefore, it can be used as a new modulating agent and anticoagulant.
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