医学
水肿
磁共振成像
同种类的
基质
肿瘤浸润淋巴细胞
核医学
总体生存率
内科学
病理
免疫组织化学
胃肠病学
放射科
癌症
免疫疗法
物理
热力学
作者
Jiejie Zhou,Yi Jin,Haiwei Miao,Shanshan Lu,Xinmiao Liu,Yun He,Huiru Liu,Youfan Zhao,Yang Zhang,Yan-Lin Liu,Zhifang Pan,Jeon‐Hor Chen,Meihao Wang,Min‐Ying Su
出处
期刊:Cancers
[MDPI AG]
日期:2023-11-30
卷期号:15 (23): 5672-5672
标识
DOI:10.3390/cancers15235672
摘要
A total of 457 patients, including 241 HR+/HER2− patients, 134 HER2+ patients, and 82 TN patients, were studied. The percentage of TILs in the stroma adjacent to the tumor cells was assessed using a 10% cutoff. The low TIL percentages were 82% in the HR+ patients, 63% in the HER2+ patients, and 56% in the TN patients (p < 0.001). MRI features such as morphology as mass or non-mass enhancement (NME), shape, margin, internal enhancement, presence of peritumoral edema, and the DCE kinetic pattern were assessed. Tumor sizes were smaller in the HR+/HER2− group (p < 0.001); HER2+ was more likely to present as NME (p = 0.031); homogeneous enhancement was mostly seen in HR+ (p < 0.001); and the peritumoral edema was present in 45% HR+, 71% HER2+, and 80% TN (p < 0.001). In each subtype, the MR features between the high- vs. low-TIL groups were compared. In HR+/HER2−, peritumoral edema was more likely to be present in those with high TILs (70%) than in those with low TILs (40%, p < 0.001). In TN, those with high TILs were more likely to present a regular shape (33%) than those with low TILs (13%, p = 0.029) and more likely to present the circumscribed margin (19%) than those with low TILs (2%, p = 0.009).
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