Organocatalytic asymmetric cascade bicyclization: Access to chiral polycyclic bisindoles from 2-indolylmethanols and propargylic alcohols
化学
级联
有机化学
立体化学
组合化学
色谱法
作者
Weiwei Zhu,Qiong Su,Xiaoyi Deng,Ze-Long Ouyang,Jiang Weng,Gui Liu
出处
期刊:Organic chemistry frontiers [The Royal Society of Chemistry] 日期:2024-01-01
标识
DOI:10.1039/d3qo01558k
摘要
We report a chiral phosphoric acid-catalyzed asymmetric cascade bicyclization of α-indolyl propargylic alcohols with 2-indolylmethanols. This highly efficient reaction affords various chiral bisindole-fused polycyclic compounds in excellent yields, as well...