嵌合抗原受体
移植
免疫学
医学
范围(计算机科学)
细胞疗法
器官移植
Treg细胞
生物
免疫疗法
细胞
免疫系统
T细胞
内科学
白细胞介素2受体
程序设计语言
遗传学
计算机科学
作者
Siawosh K. Eskandari,Andrea Daccache,Jamil Azzi
标识
DOI:10.1016/j.it.2023.11.005
摘要
In the quest for more precise and effective organ transplantation therapies, chimeric antigen receptor (CAR) regulatory T cell (Treg) therapies represent a potential cutting-edge advance. This review comprehensively analyses CAR Tregs and how they may address important drawbacks of polyclonal Tregs and conventional immunosuppressants. We examine a growing body of preclinical findings of CAR Treg therapy in transplantation, discuss CAR Treg design specifics, and explore established and attractive new targets in transplantation. In addition, we explore present impediments where future studies will be necessary to determine the efficacy of CAR Tregs in reshaping alloimmune responses and transplant microenvironments to reduce reliance on chemical immunosuppressants. Overall, ongoing studies and trials are crucial for understanding the full scope of CAR Treg therapy in transplantation.
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