医学
狼疮抗凝剂
抗磷脂综合征
假阳性悖论
系统性红斑狼疮
临床实习
重症监护医学
风险分析(工程)
免疫学
病理
物理疗法
机器学习
疾病
抗体
计算机科学
作者
Maria Efthymiou,Maria Laura Bertolaccini,Hannah Cohen
出处
期刊:Rheumatology
[Oxford University Press]
日期:2024-02-01
卷期号:63 (SI): SI54-SI63
标识
DOI:10.1093/rheumatology/kead623
摘要
Lupus anticoagulant (LA) is a well-established risk factor for the clinical manifestations of antiphospholipid syndrome (APS). Accurate LA detection is an essential prerequisite for optimal diagnosis and management of patients with APS or aPL carriers. Variability remains a challenge in LA testing, with reliable detection influenced by multiple factors, including pre-analytical conditions, anticoagulation treatment, choice of tests and procedures performed, as well as interpretation of results, that can lead to false-positives or negatives. A standardised approach to LA testing, following current guidance, based on published data and international consensus, and with attention to detail, is required to underpin accurate detection of LA. Future work should focus on better characterisation of the nature of LA, which may ultimately lead to improved diagnosis and management of patients with APS and aPL carriers. This article reviews current practice and challenges, providing an overview on detection of LA.
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