化学
戊烷
螺旋桨烷
激进的
双环分子
光化学
组分(热力学)
有机化学
热力学
物理
作者
Wenhao Xu,Zhiguo Zheng,Guoxiang Bao,Yue Wang,Yan Gao,Hui Zhu,Gongcheng Xu,Yu Zhu,Chuanming Yu,Xinpeng Jiang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-05-26
卷期号:25 (22): 4050-4055
被引量:1
标识
DOI:10.1021/acs.orglett.3c01213
摘要
Herein, we report a visible-light-induced three-component reaction involving [1.1.1]propellane, diazoates, and various heterocycles for the synthesis of 3-heteroarylbicyclo[1.1.1]pentane-1-acetates. Throughout this reaction, the radicals generated from diazoate species react with [1.1.1]propellane in an addition reaction to form bicyclo[1.1.1]pentane (BCP) radicals that subsequently react with heterocycles, leading to the formation of 1,3-disubstituted BCP acetates. Notably, this methodology exhibits excellent functional group compatibility, high atom economy, and mild reaction conditions, thus facilitating suitable synthetic access to 1,3-disubstituted BCP acetates.
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