生物相容性
化学
叶酸受体
氧化铁纳米粒子
癌症研究
癌细胞
生物物理学
药理学
纳米技术
纳米颗粒
癌症
材料科学
医学
内科学
生物
有机化学
作者
R. Shiji,Manu M. Joseph,S. Anitha,Kamala Pillai,B.S. Unnikrishnan,T.T. Sreelekha
标识
DOI:10.1016/j.ijbiomac.2022.07.185
摘要
Superparamagnetic iron oxide nanoparticles (SPIONs) represent a versatile class of theranostics with profound applications in biomedicine. An eco-friendly modification of SPIONs was attempted with a 110 kDa galactomannan (PSP001) isolated from the fruit rind of Punica granatum. The PSP001 appended SPIONs favor unique advantages including tumor-targeted accumulation and improved biocompatibility. The antineoplastic agent methotrexate (MTX) was covalently attached with the galactomannan in the SPIONs to yield PSP-IO NPs that demonstrated a reduction-sensitive drug release kinetics favoring MTX accumulation selectively in the tumor cells. Folate receptor (FR) targeted cancer cell uptake followed by the stimuli-responsive release of the payload favored improved biocompatibility and lack of toxicity in BALB/c mice. Superior tumor reduction capacity with marked survival benefits was observed in Ehrlich ascites carcinoma (EAC) bearing solid tumor mice. Phantom imaging of the carrier (PSP-IO) and the drug-loaded (PSP-IO-MTX NPs) nano-constructs generated an r2 relaxivity of 335.3 mM-1 S-1 and 333.79 mM-1 S-1 respectively indicating the remarkable contrast in magnetic resonance imaging (MRI) which was confirmed in syngraft and xenograft murine models. It is worth mentioning that PSP-IO-MTX NPs with a facile fabrication process offered an affordable nano-theranostic agent for targeted concurrent MR imaging and FR-mediated targeted tumor therapy favoring bed-side applications.
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