对映选择合成
镍
催化作用
电合成
电化学
化学
反应性(心理学)
离子液体
亲核细胞
电子转移
自由基亲核芳香族取代
有机化学
组合化学
亲核取代
亲核芳香族取代
病理
物理化学
医学
替代医学
电极
作者
Qinglin Zhang,Kang Liang,Chang Guo
标识
DOI:10.1002/anie.202210632
摘要
Abstract A simplified and appealing strategy via a chiral catalyst to facilitate the electrochemical process and provide asymmetric induction of radical reactions is particularly desirable and would have potential applications in electrosynthesis, organic chemistry, and drug discovery. Here, we introduced a novel electrolytic system that diverts the standard ionic reactivity to new catalytic functions, enabling mechanistically distinct single‐electron transfer‐based enantioselective routes to exhibit a brand‐new pattern of reactivity—electricity‐driven asymmetric catalysis as a privileged chiral platform for enantioselective radical allylation. The nickel‐catalyzed activation of nucleophiles triggered a single‐electron transfer process to provide a chiral catalyst‐bound radical cation intermediate, which could be applied as an alternative strategy for the development of stereocontrolled radical reactions.
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