原子力显微镜
细胞外小泡
液体活检
小泡
纳米技术
生物物理学
癌细胞
化学
癌症
材料科学
细胞生物学
生物
医学
生物化学
膜
内科学
作者
Yang Feng,Meichen Liu,Xinxin Li,Mi Li,Xiaojing Xing,Lianqing Liu
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-02-01
卷期号:23 (4): 1591-1599
被引量:5
标识
DOI:10.1021/acs.nanolett.3c00093
摘要
Cells release extracellular vesicles (EVs) as the carriers for intercellular communications to regulate life activities. Particularly, it is increasingly apparent that mechanical forces play an essential role in biological systems. The nanomechanical properties of EVs and their dynamics in cancer development are still not fully understood. Herein, with the use of atomic force microscopy (AFM), the nanomechanical signatures of EVs from the liquid biopsies of hematologic cancer patients were unraveled. Single native EVs were probed by AFM under aqueous conditions. The elastic and viscous properties of EVs were measured and visualized to correlate EV mechanics with EV geometry. Experimental results remarkably reveal the significant differences in EV mechanics among multiple myeloma patients, lymphoma patients, and healthy volunteers. The study unveils the unique nanomechanical signatures of EVs in hematologic cancers, which will benefit the studies of liquid biopsies for cancer diagnosis and prognosis with translational significance.
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