[Genomic structure of varicella-zoster virus and its vaccine application status].

With the determination of the whole genome sequence of varicella-zoster virus (VZV) virus, the successful breakthrough of infectious cloning technology of VZV, and the emergence of effective preventive vaccines, which have been proven to be effective and safe, varicella has become a disease preventable by specific immunity. This article will review the genomic structure, epidemiological characteristics, and research application progress of varicella vaccine and herpes zoster vaccine of varicella zoster virus to provide reference for primary prevention of the disease.随着水痘-带状疱疹病毒（VZV）的全基因组序列测定、VZV感染性克隆技术成功突破，有效预防疫苗不断出现，并被证实其良好的有效性及安全性，水痘已成为一种可通过特异性免疫预防的疾病。本文将从VZV的基因组学结构、流行病学特点、水痘疫苗与带状疱疹疫苗研究应用进展等方面进行阐述，为疾病一级预防提供参考。.