METTL3 potentiates osteogenic differentiation of bone marrow mesenchymal stem cells via IGF2BP1/m6A/RUNX2

OBJECTIVE: -methyladenosine during BMSCs osteogenic differentiation BMSCs. SUBJECT AND METHODS: Biofunctions of BMSCs were detected using ALP activity and alizarin red S staining assays. The molecular interaction within RNA/protein was identified by RNA immunoprecipitation and/or methylation immunoprecipitation. RESULTS: A site on RUNX2 mRNA to enhance its stability. CONCLUSION: A-dependent manner, providing a potential therapeutic target for maxillofacial bone defects treatment.