化学
卡宾
均分解
异氰
催化作用
组合化学
发散合成
卤化物
有机化学
激进的
作者
Qianrong Li,Cong‐Ying Zhou,Chengming Wang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-10-11
卷期号:24 (41): 7654-7658
被引量:8
标识
DOI:10.1021/acs.orglett.2c03148
摘要
A variety of phenanthridines are rapidly constructed by an N-heterocyclic carbene (NHC)-catalyzed SOMOphilic isocyanide insertion-initiated homolytic aromatic substitution-type radical cyclization in the absence of any light, transition metals, and external oxidants. The aldehyde-free, scalable, and operationally simple protocol tolerates diverse functionalized biaryl isonitriles and activated α-halides. Moreover, it can be further applied to the divergent construction of other N-heterocycles. Preliminary mechanistic studies disclose that an NHC-derived radical cation intermediate is possibly involved.
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