Metal–Organic Framework‐Derived Homologous Sulfide Heterojunction for Robust Enzyme‐Like Self‐Driven Bacteria‐Killing through Enhanced Electron Transfer

Abstract Infectious diseases caused by various bacteria pose a serious threat to human health, and the emergence of drug‐resistant bacteria has forced humans to develop new and effective antimicrobial agents and strategies. Herein, a metal–organic framework‐derived Bi 2 S 3 /FeS 2 heterojunction (BFS) is synthesized, and the materials–microorganism interface is further constructed. Through interfacial electron transfer, electrons are transferred from the bacteria to the BFS surface, disrupting the balance of the bacterial electron transport chain and inhibiting the metabolic activity of the bacteria. Moreover, BFS has enzyme‐like (oxidase and peroxidase) properties and can produce a large amount of reactive oxygen species to kill additional bacteria. In vitro antibacterial results show that the antibacterial efficiency of BFS against both Staphylococcus aureus and Escherichia coli reaches more than 99.9% after 4 h of co‐culture under dark conditions. Meanwhile, in vivo experiments show that BFS can effectively kill bacteria and promote wound healing. This work shows that BFS could be a novel, effective nanomaterial for the treatment of bacterial infections by constructing the materials–microorganism interface.