The aim of this work was to study Pb accumulation in indoor dust, and health risk of human due to dust exposure. Risk assessment of Pb to human health: Pb is most harmful to human body. The reasons of non-carcinogenic risk in residential area may be that indoor is not swept regularly, in addition, indoor decoration, building materials and other factors may also affect the content of Pb in dust. Non-carcinogenic risk in children is not only more than adults but also beyond the safety threshold. Indoor dust has been a threat to the health of children in Shenyang.