Organocatalytic Enantioselective Cascade Michael–Aldol Condensation Reactions: Efficient Assembly of Densely Functionalized Chiral Cyclopentenes

A cascade of possibility: A novel and highly enantioselective cascade Michael–aldol condensation reaction of α,β-unsaturated aldehydes with dimethyl malonate aldehyde has been developed. The process, efficiently catalyzed by a simple chiral diphenylprolinol TES ether, serves as a powerful approach to the preparation of highly functionalized chiral cyclopentenes with the formation of two new CC bonds. TES=triethylsilyl. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z703163_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.