斑节对虾
哈维氏弧菌
小虾
生物
免疫刺激剂
微生物学
免疫系统
先天免疫系统
基因表达
模式识别受体
免疫学
弧菌
基因
细菌
渔业
生物化学
遗传学
作者
Mundanda Muthappa Dechamma,Moger Rajeish,Biswajit Maiti,Madhu K. Mani,Indrani Karunasagar
标识
DOI:10.1016/j.aqrep.2015.02.002
摘要
The Toll-like receptors (TLR), being pattern recognition molecules, are a powerful first line of defense in response to pathogen invasion. They are known to play a crucial role in detecting and binding to the microbial molecule and triggering a non-specific immune response. Quantitative real time PCR (qPCR) expression of the TLR gene was studied in healthy and Vibrio harveyi infected black tiger shrimp (Penaeus monodon). Lymphoid tissue expression of TLR in V. harveyi infected animals 24 h post injection showed statistically significant up regulation of the gene as compared to the control animals sham injected with phosphate buffered saline (PBS). The qPCR expression pattern of TLR at different time points in shrimp administered with the immunostimulant glucan for 6 days by oral feeding followed by challenge with V. harveyi showed statistically significant level at 48 h post bacterial challenge as compared to the control (immunostimulant treated) animals sham injected with PBS. The novelty of the study is that it elicits the role of TLRs as important response proteins of the innate immune system in the shrimp.
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