During polymer flooding, certain amount of polymer would be lost. Polymer retention causes sweep volume expanding on one side, it also causes polymer loss on the other. Therefore, it is a very important topic to study the influencing factors of polymer retention. There are many factors affecting polymer retention process. This paper mainly studied the influence from dynamic factors such as polymer solution concentration, injection rate, injection time, injected pv number. This paper investigated the influence of these factors on polymer retention process, and optimized these factors to minimize polymer loss in reservoir.