结直肠癌
医学
免疫组织化学
肿瘤科
内科学
阶段(地层学)
临床意义
癌症
多元分析
总体生存率
自噬
微卫星不稳定性
生存分析
基因
细胞凋亡
生物
微卫星
古生物学
等位基因
生物化学
作者
Zhaohui Yang,Roshan Ara Ghoorun,Xinjuan Fan,Peihuang Wu,Yang Bai,Jizheng Li,Chunyan Hao,Lei Wang,Jianping Wang
标识
DOI:10.1016/j.clinre.2014.06.014
摘要
Beclin-1 is an autophagy gene. It promotes the formation of the autophagic vesicle as well as plays an essential role in guarding the cells against chromosomal instability. Overexpression of Beclin-1 has been reported to predict a favorable survival in various cancers. However, little is known about its prognostic significance in colorectal cancer. A total of three hundred and sixty-three (363) colorectal tissues from colorectal cancer (CRC) patients were collected. Tissue micro-arrays and immunohistochemistry were used to investigate the expression and prognostic significance of Beclin-1 in CRC. The associations among Beclin-1 expression, clinicopathological parameters and prognosis were evaluated. Beclin-1 had a higher expression in CRC tissues than in normal tissues. A high expression of Beclin-1 was positively correlated with gender (P = 0.027), histological grade (P = 0.003), pM status (P = 0.003) and clinical stage (P = 0.024). Patients with a high Beclin-1 expression, when compared to those with a lower expression had both a better overall survival (OS, P = 0.006) and disease-free survival (DFS, P = 0.008). In the pT3 subgroup, Beclin-1 was also found to be a good prognostic indicator (P < 0.05). Multivariate analysis showed a high expression of Beclin-1 was indeed a positive independent prognostic factor of OS and DFS for CRC patients (P < 0.05). Our results demonstrated that a high expression of Beclin-1 correlated with a better overall survival and disease-free survival, thus serving as a favorable independent prognostic marker in CRC.
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