细胞凋亡
化学
细胞周期蛋白依赖激酶1
立体化学
机制（生物学）
细胞周期检查点
组合化学
细胞周期
生物化学
物理
量子力学
作者
Shahla Karim Baloch,Lin Ma,Xueliang Wang,Jing Bo Shi,Yu Zhu,Fengyao Wu,Yan‐Jun Pang,Guihua Lu,Jinliang Qi,Xiaoming Wang,Hongwei Gu,Yonghua Yang
出处
期刊：RSC Advances
[Royal Society of Chemistry]
日期：2015-01-01
卷期号：5 (40): 31759-31767
被引量：15
摘要
Novel shikonin derivatives were synthesised and probed as anticancer agents. Compound 40 showed the best anticancer activity with an IC50 of 1.26 μM, could induce apoptosis and cause cell cycle arrest at the G2/M phase via the P21 p-CDC2 (Tyr15) pathway independent of P53.
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