细胞外基质
整合素
细胞生物学
细胞粘附
粘附
化学
细胞粘附分子
基质(化学分析)
生物
细胞
生物化学
色谱法
有机化学
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2009-11-27
卷期号:326 (5957): 1216-1219
被引量:2750
标识
DOI:10.1126/science.1176009
摘要
The extracellular matrix (ECM) and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases. The ECM has many effects beyond providing structural support. ECM proteins typically include multiple, independently folded domains whose sequences and arrangement are highly conserved. Some of these domains bind adhesion receptors such as integrins that mediate cell-matrix adhesion and also transduce signals into cells. However, ECM proteins also bind soluble growth factors and regulate their distribution, activation, and presentation to cells. As organized, solid-phase ligands, ECM proteins can integrate complex, multivalent signals to cells in a spatially patterned and regulated fashion. These properties need to be incorporated into considerations of the functions of the ECM.
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