细胞滋养层
合胞滋养细胞
滋养层
胎儿
男科
绒毛
外周血
妊娠期
怀孕
生物
医学
胎盘
免疫学
遗传学
作者
Utz Mueller,C.S. Hawes,Aisling Wright,E. DeBoni,Warren Jones,F A Firgaira,Alexander A. Morley,David R. Turner
出处
期刊:The Lancet
[Elsevier BV]
日期:1990-07-01
卷期号:336 (8709): 197-200
被引量:197
标识
DOI:10.1016/0140-6736(90)91731-o
摘要
Abstract
Fetal trophoblast cells were isolated from maternal peripheral blood by means of murine monoclonal antibodies of high specificity and affinity for human syncytiotrophoblast and nonvillous cytotrophoblast cells. The cells were isolated in sufficient numbers to allow polymerase chain reaction (PCR) amplification of the Y-chromosome-specific DNA sequence from the peripheral blood of thirteen pregnant women. The fetal sex predicted by PCR analysis of the isolated trophoblast cells accorded with that ascertained by karyotyping of chorionic villus samples in eleven of twelve women studied in early pregnancy and with the sex of the baby on delivery in one woman studied at 34 weeks' gestation. Isolation of these fetal cells could allow non-invasive diagnosis of a wide range of inherited disorders.
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