生物
免疫系统
效应器
免疫
功能(生物学)
细胞代谢
细胞生物学
平衡
免疫学
获得性免疫系统
细胞
遗传学
作者
Michael D. Buck,Ryan Sowell,Susan M. Kaech,Erika L. Pearce
出处
期刊:Cell
[Elsevier]
日期:2017-05-01
卷期号:169 (4): 570-586
被引量:849
标识
DOI:10.1016/j.cell.2017.04.004
摘要
Choices have consequences. Immune cells survey and migrate throughout the body and sometimes take residence in niche environments with distinct communities of cells, extracellular matrix, and nutrients that may differ from those in which they matured. Imbedded in immune cell physiology are metabolic pathways and metabolites that not only provide energy and substrates for growth and survival, but also instruct effector functions, differentiation, and gene expression. This review of immunometabolism will reference the most recent literature to cover the choices that environments impose on the metabolism and function of immune cells and highlight their consequences during homeostasis and disease.
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